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Chain conformation and intermolecular interaction of partially neutralized poly(acrylic acid) in dilute aqueous solutions

The isoionic dilution method was used to measure the intrinsic viscosity, [η], and the Huggins coefficient, K(H), of two poly(acrylic acid) samples, 50% neutralized with NaOH, with molecular weights 5.0 x 103 (Na50PA5) and 4.8 x 104 (Na50PA48) at different ionic strengths. For Na50PA5 at low ionic strength, [η] is higher than the value predicted by a rigid-rod model. Assuming that the chain has re

Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

Trait-associated loci often map to genomic regions encoding long noncoding RNAs (lncRNAs), but the role of these lncRNAs in disease etiology is largely unexplored. We show that a pair of sense/antisense lncRNA (6p22lncRNAs) encoded by CASC15 and NBAT1 located at the neuroblastoma (NB) risk-associated 6p22.3 locus are tumor suppressors and show reduced expression in high-risk NBs. Loss of functiona

Separate and combined associations of obesity and metabolic health with coronary heart disease : A pan-European case-cohort analysis

Aims: The hypothesis of 'metabolically healthy obesity' implies that, in the absence of metabolic dysfunction, individuals with excess adiposity are not at greater cardiovascular risk We tested this hypothesis in a large pan-European prospective study. Methods and results: We conducted a case-cohort analysis in the 520 000-person European Prospective Investigation into Cancer and Nutrition study (

A retrospective investigation of hexavalent chromium allergy in southern Sweden

Background: Historically, allergic contact dermatitis caused by hexavalent chromium [Cr(VI)] in cement was the most common cause of invalidity attributable to skin disease in Sweden. Since the legislation to reduce Cr(VI) in cement was introduced in 1989, we rarely see allergic contact dermatitis caused by cement. Objectives: To examine the frequency of contact allergy to Cr(VI) in southern Sweden

Cerebrospinal Fluid Cytokines and Neurotrophic Factors in Human Chronic Pain Populations : A Comprehensive Review

Chronic pain is a prevalent and debilitating condition, conveying immense human burden. Suffering is caused not only by painful symptoms, but also through psychopathological and detrimental physical consequences, generating enormous societal costs. The current treatment armamentarium often fails to achieve satisfying pain relief; thus, research directed toward elucidating the complex pathophysiolo

Bridging the contradictions of social constructionism and psychoanalysis in a study of workplace emotions in India

This paper makes a contribution to the study of emotions in organizations by offering a systematic juxtaposition and cross-fertilization of psychoanalytic and social constructionist approaches. These two traditions have found it hard to communicate in the past when addressing organizational emotions. Points of similarity and tension between them are discussed in connection with two critical case s

The caring leader – What followers expect of their leaders and why?

This paper examines the moral standing of leaders not from any particular philosophical or political vantage point, but rather from that of the followers. Followers expect leaders to be competent just as they expect professionals and others; but they also expect leaders to provide moral leadership. Followers frequently judge leaders by standards of morality that are considerably harsher than those

The bat–bird–bug battle : Daily flight activity of insects and their predators over a rice field revealed by high-resolution scheimpflug lidar

We present the results of, to our knowledge, the first Lidar study applied to continuous and simultaneous monitoring of aerial insects, bats and birds. It illustrates how common patterns of flight activity, e.g. insect swarming around twilight, depend on predation risk and other constraints acting on the faunal components. Flight activity was monitored over a rice field in China during one week in

Biological wound matrices with native dermis-like collagen efficiently modulate protease activity

Objective: When the delicate balance between catabolic and anabolic processes is disturbed for any reason, the healing process can stall, resulting in chronic wounds. In chronic wound pathophysiology, proteolytic imbalance is implicated due to elevated protease levels mediating tissue damage. Hence, it is important to design appropriate wound treatments able to control and modulate protease activi

Connection between BMI-Related Plasma Metabolite Profile and Gut Microbiota

Context Emerging evidence has related the gut microbiome and circulating metabolites to human obesity. Gut microbiota is responsible for several metabolic functions, and altered plasma metabolome might reflect differences in the gut microbiome. Objective To identify a plasma metabolite profile associated with body mass index (BMI) in a general population and investigate whether such metabolite pro