BackgroundComplement activation in atypical hemolytic uremic syndrome (aHUS), C3 glomerulonephropathy (C3G) and immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) may be associated with rare genetic variants. Here we describe gene variants in the Swedish and Norwegian populations.MethodsPatients with these diagnoses (N=141) were referred for genetic screening. Sanger or nex

When two putatively cryptic species meet in nature, hybrid zone analysis can be used to estimate the extent of gene flow between them. Two recently recognized cryptic species of banded newt (genus Ommatotriton) are suspected to meet in parapatry in Anatolia, but a formal hybrid zone analysis has never been conducted. We sample populations throughout the range, with a focus on the supposed contact

Species with wide-range distributions usually display high genetic variation. This variation can be partly explained by historical lineages that were temporally isolated from each other and are back into secondary reproductive contact, and partly by local adaptations. The smooth newt ( Lissotriton vulgaris) is one of the most widely distributed amphibians species across Eurasia and forms a species

This paper discusses the morpho-syntax of phrasal proper names likeDeutsche Bahn ‘German Railway’ and Norske Skog ‘Norwegian Forest’ in Germanand Norwegian. As regards determiner elements, there are three types of phrasalproper names in German: some proper names do not have a definite article, some do,and yet others exhibit a possessive. Depending on the syntactic context, the first twotypes patteThis paper discusses the morpho-syntax of phrasal proper names like Deutsche Bahn ‘German Railway’ and Norske Skog ‘Norwegian Forest’ in German and Norwegian. As regards determiner elements, there are three types of phrasal proper names in German: some proper names do not have a definite article, some do, and yet others exhibit a possessive. Depending on the syntactic context, the first two types

Introduction and hypothesisThe mid-urethral sling (MUS) has been used for more than 30 years to cure stress urinary incontinence. The objective of this study was to assess whether surgical technique affects the outcome after more than ten years, regarding dyspareunia and pelvic pain.MethodsIn this longitudinal cohort study we used the Swedish National Quality Register of Gynecological Surgery to i

In recent years the list of disorders affecting amino acid synthesis has grown rapidly. Not only the number of defects has increased, but also the associated clinical phenotypes have expanded spectacular, the latter mainly due to the advances of next-generation sequencing diagnostics. An important reason for the contribution of NGS in the diagnosis of amino acid synthesis disorders is the fact tha

In both the US and EU, policymakers and government agencies are acknowledging theimportance of having access to repair options, particularly for vulnerable product users who depend on their products. As such, repair can play an important role as a resource for resilience, but research is missing. We propose that repair can act as a resource for resilience. A comprehensive, structured way to unders

Two decades into the young history of e-participation research, we aim to take stock of the state of this field in the light of three developments that we argue have substantial implications for research on electronic participation:(1) dissolving boundaries between online and offline spheres of political participation;(2) academic isolation of e-participation research from other research fields re

The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from lack of interpretability. Here, we present a deep learning approach to combine biological pathway analysis and biomarker identification to increase the interp

Finding alternative and sustainable ways to produce, store and convert energy is key for reducing fossil fuel-based CO2 emissions. In this transformation, hydrogen for energy storage and hydrogen-powered fuel cells for energy conversion can play important roles. However, storage of hydrogen itself is difficult and the concept of reversible liquid organic hydrogen carriers (LOHCs) has been proposed

Tactile feedback plays a vital role in inducing ownership and improving motor control of prosthetic hands. However, commercially available prosthetic hands typically do not provide tactile feedback and because of that the prosthetic user must rely on visual input to adjust the grip. The classical rubber hand illusion (RHI) where a brush is stroking the rubber hand, and the user's hidden hand synch

This article investigates solidarity as a concept and/or a norm of EU law from the perspective of functional constitutionalism. It asks how solidarity fits within the normative framework of the EU legal order if we understand this framework as being founded on a functional constitution.Under functional constitutionalism, the EU is understood as a purposive polity and the authority of the legal ord

In 303 Creative LLC et al. v Elenis, the US Supreme Court held that the petitioners were entitled to refuse to provide wedding website services in respect of same sex weddings, and to post a notice on their website stating that they would not provide such services.The case was framed as concerning the freedom of speech of the website designer (Ms Lorie Smith), although the main petitioner was not

Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis. Here we describe the development of an assay method for activity fingerprinting of AMR β-lactamases using panels of 7 β-lactam antibiotics in 35 min. New Deli Metallo β