INTRODUCTION: β-Synuclein is an emerging synaptic blood biomarker for Alzheimer's disease (AD) but differences in β-synuclein levels in preclinical AD and its association with amyloid and tau pathology have not yet been studied. METHODS: We measured plasma β-synuclein levels in cognitively unimpaired individuals with positive Aβ-PET (i.e., preclinical AD, N = 48) or negative Aβ-PET (N = 61), Aβ-po

To avoid the scaling of the number of qubits with the size of the basis set, one can divide the molecular space into active and inactive regions, which is also known as complete active space methods. However, selecting the active space alone is not enough to accurately describe quantum mechanical effects such as correlation. This study emphasizes the importance of optimizing the active space orbit

Non-technical summary The United Nations' sustainable development goals (SDGs) articulate societal aspirations for people and our planet. Many scientists have criticised the SDGs and some have suggested that a better understanding of the complex interactions between society and the environment should underpin the next global development agenda. We further this discussion through the theory of soci

Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the e

Behovet av att ersätta konventionell fossilbaserad plast blir allt viktigare. Eftersom klimatförändringarna mer synligt påverkar vårt samhälle, förvärrar det problemet att använda icke-hållbara resurser för att tillverka plast. Dessutom hamnar dessa långvariga, icke-återvunna avfall i våra hav, vilket skapar ett inneboende miljöföroreningsproblem. Att forska om nya biobaserade byggstenar för att mThe need to replace conventional fossil-based plastics is becoming more imperative. As climate change is more visibly affecting our society, employing non-sustainable resources to produce plastics is aggravating the problem. Moreover, these long-lasting, non-recycled wastes end up in our oceans, creating an intrinsic environmental pollution problem. Researching new biobased building blocks to enab

Due to desirable optical properties, such as efficient luminescence and large Stokes shift, DNA-templated silver nanoclusters (DNA-AgNCs) have received significant attention over the past decade. Nevertheless, the excited-state dynamics of these systems are poorly understood, as studies of the processes ultimately leading to a fluorescent state are scarce. Here we investigate the early time relaxa

Background: Insulin resistance has been shown to be related to a higher risk of several cancers, but the association with prostate cancer (PCa) has been inconsistent. Methods: We investigated prediagnostic markers of insulin resistance in men in four cohorts in Sweden, in relation to PCa risk (total, non-aggressive and aggressive) and PCa death using multivariable-adjusted Cox regression. The numb

This article is about territorial claims, authority and rights in an urban settlement or ‘bosti’ in central Dhaka. It highlights the drama of a violent encounter between a police officer and a young man, unfolding how the social ordering of urban space is (re)produced in and through authority and violence. It illustrates how situated practices of authority define who can access institutions of rig

We investigate the tetragonal phase of the binary transition metal oxide CuO (t-CuO) within the context of cellular dynamical mean-field theory. Due to its strong antiferromagnetic correlations and simple structure, analysing the physics of t-CuO is of high interest as it may pave the way towards a more complete understanding of high-temperature superconductivity in hole-doped antiferromagnets. In

This article contributes to scholarly discussions about sanctuary enactments. We analyse transversal sanctuary enactments, i.e. when migrants in search of protection are provided with basic welfare and an opportunity to remain, in contestation of the state’s migration politics. The study draws on empirical data collected through a transdisciplinary research initiative in Sweden, the Asylum Commiss

There is an increasing body of evidence, based on well-controlled clinical trials and long-term follow-up, that liposuction can result in significant objective and subjective benefit to patients who have long-term chronic primary or secondary lymphedema. There are, however, different views on the immediate, short-, and long-term benefits of liposuction for treating lymphedema, with a strong dichot

BACKGROUND: The melanoma-specific survival (MSS) is heterogenous between stages and is highly dependent on the T stage for primary localized disease. New systemic therapies for metastatic cutaneous melanoma (CM) have been introduced since 2012 in Sweden.OBJECTIVES: To analyse the incidence and MSS time trends between 1990 and 2020 in Sweden.METHODS: Nationwide, population-based, and prospectively

An emissions barrier was installed in a building where a wall had been treated with a tar-containing material as an impregnation agent and moisture barrier. There was a strong disturbing smell inside the building. Several polycyclic aromatic hydrocarbons (PAH) were identified in the indoor air amounting to a total of 1726 ng PAH/m3. The amounts decreased to 139 ng/m3 after the barrier had been ins

Degenerative meniscus lesions have been associated with both osteoarthritis etiology and its progression. We, therefore, sought to establish a human meniscus ex vivo model to study the meniscal response to cytokine treatment using a proteomics approach. Lateral menisci were obtained from five knee-healthy donors. The meniscal body was cut into vertical slices and further divided into an inner (ava

Many deltas are increasingly threatened by environmental change, including climate change-induced sea-level rise, land subsidence and reduced sediment delivery. Dealing with these challenges is a pressing necessity because deltas are home to many people and are important centres for economic and agricultural development. Successfully adapting to climate change requires a social-ecological system (